Histo-morphological Spectrum of Cystoscopic Biopsies in Kathmandu Model Hospital

Abstract

Introduction: Urinary bladder lesions are commonly encountered medical problems. Both non-neoplastic and neoplastic lesions are significant causes of morbidity. However, malignant lesions usually result in mortality. Cystoscopy guided biopsy determines the nature of lesion and thus helps in further management of patients. The objectives of this study were to find out the histo-pathological diagnosis and features of various bladder lesions and their frequencies.
Methods: This cross-sectional study was carried out in the Department of Pathology, Kathmandu Model Hospital. All the cystoscopic biopsies received from January 2021 to December 2023 were included in the study. Preserved tissue slides were examined under a light microscope by the primary investigator. The histo-pathological diagnosis of each lesion was recorded, along with specific features such as tumor type, grade and depth of invasion.
Results: Total 47 cystoscopic biopsies were studied. The majority of patients 12 (25.5%) were in age group 70-80 years and predominant 31 (66%) were male. Neoplastic lesions were more common 31 (66%) and infiltrating and non-invasive urothelial carcoinoma constituted equal in number 14 each (45%). Among the non-neoplastic lesions, non-specific cystitis was the commonest 13 (82%). 
Conclusion: Neoplastic lesions are more common than non-neoplastic lesions. Neoplastic lesions are more common in male and in age group 70-79 years. Infiltrating and non-invasive urothelial carcinoma are equally common. Non-specific cystitis is the commonest among the non-neoplastic lesions.